Milestone Research Projects

ISHS-CCIH has been engaged in various research activities. It has been involved in evidence-based Ayurveda and integrative medicine as well as meta-research, analysis, policy advocacy and thought leadership in AYUSH research. The milestone research projects undertaken so far are:

Projects
Ongoing

  • Indian Human Microbiome Initiative (Department of Biotechnology) (2020-2022)

  • Awarded with DBT, THSTI: Preclinical Evaluations of Select AYUSH Herbal Extracts / Formulations for Mitigating SARS- CoV2 and Associated Pathologies. Funded by Department of Biotechnology – and Ministry of AYUSH, Government of India under special call, “DBT-AYUSH Network on SARS-COV-2 virus and COVID-19 disease”. (2020-2021)

    •
Completed

  • Role of Ayurvedic Rasayanas in Osteogenic and Adipogenic differentiation of Human Umbilical Cord derived Mesenchymal Stem Cells in 3D culture and diseased animal models (Department of Science and Technology under Ayurvedic Biology Program, Collaborator: Sinhagad College of Engineering. Project.) (completed) (2017-2019)

  • Network ethnopharmacological investigation for natural phosphodiesterase inhibitors (2015 – 2017)

  • Herb-Drug Interactions between prescription drugs and herbal drugs during treatment of diabetes (2013 – 2015)

  • AyuGenomics: ‘Genomic Variation Analysis and Gene Expression Profiling of Human Dosha Prakriti based on Principles of Ayurveda’ (2007 – 2011)

  • Development of novel herbal adjuvants for vaccines’ was undertaken in collaboration with Serum Institute of India Pvt. Ltd (2004 – 2007)

  • Development of AyuSoft – An intelligent decision support system based on Ayurvedic knowledge’ was conducted in collaboration with Center for Development of Advance Computing (C-DAC), Pune (2003 – 2006)

  • New Millennium Indian Technology Leadership Initiative (NMITLI): ‘Development of Ayurveda based formulations for treatment of arthritis’ (2002 – 2006)

    •
Research programs

Winter School on Transdisciplinary Research (a DHR Project)
The AYUSH-CoE team participated in organization of Winter School on transdisciplinary research for integrative health. The Winter School was a one-month residential (15th Nov-2018 to 15th-Dec-2018) program funded by the Department of Health Research (DHR), Ministry of Health and Family Welfare, Government of India and SPPU.

The training modules covered during the Winter School are enlisted below:

  • Evidence Based Medicine and Integrative Health
  • Drug Discovery Sciences
  • Nutritional Biochemistry
  • Introduction to Molecular Biology and Ayurvedic Biology
  • Complementary Medicine and Public Health
  • Systems Biology
  • Epidemiology and Pharmacoepidemiology
  • Biostatistics and Quantitative Methods

The highlights of the DHR Winter School 2018 were as follows:

  • One-month residential training program
  • Participants from traditional (AYUSH) and modern sciences (life sciences and biomedical sciences)
  • 30 participants from 16 states of India and one participant from Nepal
  • More than 60 resource persons guided the participants
  • Unique blend of Gurukul and University systems
  • Peer group learning
  • Innovative pedagogy methods comprising group interaction, panel discussion, lab visits, field visits, fun and learn activities
Publications (2015-present)
Articles

2020

  1. Lele RD., Patwardhan B. Transiting from pathy-based to people-centered holistic healthcare. J AyurvedaIntegr Med 2020;11(3):A1.
  2. Patwardhan B., Desiraju GR. Assessing research: the slippery slope. Curr Sci. 2020;118(12):1869-1870
  3. Mittal P., Radkar A., Kurup A., Kharola A., Patwardhan B. Measuring Access, Quality and Relevance in Higher Education. Econ Polit Wkly. 2020;55(24):34-38.
  4. Saggam, A., Tillu, G., Dixit, S., et al Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer. J Ethnopharmacol. 2020; 255:112759.
  5. Patwardhan, B., Chavan-Gautam, P., Gautam, M. Ayurveda rasayana in prophylaxis of COVID-19. Curr Sci. 2020; 118(8):1158-1160.
  6. Tillu, G., Chaturvedi, S., Chopra, A., Patwardhan, B. Public Health Approach of Ayurveda and Yoga for COVID-19 Prophylaxis. J Altern Complement Med.2020;26(5): 360-364.
  7. Tillu, G., Salvi, S., Patwardhan, B. AYUSH for COVID-19 management J AyurvedaIntegr Med. 2020;11(2): 95-96
  8. Chaturvedi S, Kumar N, Tillu G, Deshpande S, Patwardhan B. AYUSH, modern medicine and the Covid-19 pandemic. Indian J Med Ethics. 2020;5(3):191-5.
  9. Borse SP, Chhipa AS, Singh DP, Sharma V, Nivsarkar M. Management of Type 2 Diabetes: Current strategies, unfocussed aspects, challenges and alternatives. Med Princ Pract. 2020.
  10. Sharma V, Rana R, Baksi B, Borse SP, Nivsarkar M. Light-controlled calcium signaling in prostate cancer and benign prostatic hyperplasia. Futur J Pharm Sci. 2020; 6:28.
  11. Rani, A., Chavan-Gautam, P., Mehendale, S., et al. Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia. Placenta2020;95:33-43.

2019

  1. Patwardhan B., Patwardhan K. Contesting Predators: Cleaning Up Trash in Science. J Altern Complement Med.2019;25(10):979-982
  2. Patwardhan B, Thakur A. UGC-CARE initiative to promote research quality, integrity and publication ethics. Curr Sci. 2019;117(6):918-919.
  3. Shengule SA, Mishra S., Patil D., Joshi KS., Patwardhan B. Phytochemical characterization of ayurvedicformulations of Terminalia arjuna: A potential tool for quality assurance. Indian J Tradit Know. 2019;18(1).
  4. Grudniewicz A., Moher D., Cobey KD., et al. Predatory journals: no definition, no defence. Nature. 2019;576(7786): 210-212
  5. Girme A., Saste G., Ghule C., et al. Phytoanalytical profiling of Cassia auriculata by LC-PDA-ESI-MS/MS and HPTLC supporting its metabolic claims. Planta Medica. 2019;85(18):022.
  6. Tillu, G. AYUSH and meta-research. J AyurvedaIntegr Med. 2019;10(3):157-158.
  7. Mutalik, G., Tillu, G., Patwardhan, B. AyurYoga, the confluence of healing sciences: A call for global action. J AyurvedaIntegr Med. 2019;10(2):79-80.
  8. Chhipa AS., Borse SP., Baksi R., Lalotra S., Nivsarkar M. Targeting Receptors of Advanced Glycation End Products (RAGE): Preventing diabetes induced cancer and diabetic complications. Pathol Res Pract. 2019;215(11):152643.
  9. Fofie, C.K., Katekhaye, S., Borse, S., et al. Antidiabetic properties of aqueous and methanol extracts from the trunk bark of Ceiba pentandra in type 2 diabetic rat. J Cell Biochem. 2019;120(7):11573-11581.

2018

  1. Patwardhan B., Payyappalli U. Ayurveda and anti-microbial resistance. J AyurvedaIntegr Med. 2019;9(2):85.
  2. Patwardhan B, Nagarkar S, Gadre SR, Lakhotia SC, Katoch VM, D Moher D. A critical analysis of the'UGC-approved list of journals. Curr. Sci 2019;114 (6):00113891.
  3. Tillu, G. AYUSH research for New India: Vision and strategies. J AyurvedaIntegr Med. 2018;9(3):240-244.
  4. Patwardhan, B., Tillu, G. A tribute to the visionaries. J AyurvedaIntegr Med. 2018;9(3):159-160.
  5. Patwardhan, B., Tillu, G. Universal Health Coverage and AYUSH systems. J AyurvedaIntegr Med. 2018;9(1):1-2.
  6. Kemse, N., Kale, A., Chavan-Gautam, P., Joshi, S. Increased intake of vitamin B12, folate, and omega-3 fatty acids to improve cognitive performance in offspring born to rats with induced hypertension during pregnancy. Food and Function. 2018;9(7): 3872-3883.
  7. Sahay, AS., Jadhav, AT., Sundrani, DP. VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae. Mol Cell Biochem. 2018;438(1-2):141-152.
  8. Borse, SP., Singh, DP., Upadhyay, D., Nivsarkar, M. Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats. Food Chem Toxicol. 2018;120:448-46.
  9. Baksi, R., Singh, DP., Borse, SP. In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. Biomed Pharmacother. 2018;106:1513-1526.
  10. Chavan-Gautam, P., Rani, A., Freeman, DJ. Distribution of Fatty Acids and Lipids During Pregnancy. Adv Clin Chem. 2018;84:209-239.
  11. Shengule S, Kumbhare K, Patil D, Mishra S, Apte K, Patwardhan B. Herb-drug interaction of Nisha Amalaki and Curcuminoids with metformin in normal and diabetic condition: A disease system approach. Biomed Pharmacother. 2019;101:591-598.

2017

  1. Chaturvedi S, Patwardhan B. India's Indigenous Medical Systems: A cross-disciplinary approach. Natl Med J India. 2017;30(6):360.
  2. Shankar D, Patwardhan B. AYUSH for New India: Vision and strategy. J AyurvedaIntegr Med. 2017;8(3):137.
  3. Patwardhan K, Patwardhan B. Ayurveda education reforms in India. J AyurvedaIntegr Med. 2017;8(2):59.
  4. Mukherjee PK., Katiyar CK., Patwardhan B. Special issue on Ayurveda. J Ethnopharmacol. 2017;197:2.
  5. Chandran U, Patwardhan B. Network ethnopharmacological evaluation of the immunomodulatory activity of Withania somnifera. J Ethnopharmacol. 2017;197:250-256.
  6. Chaturvedi S, Raven J, Patwardhan B. Addressing child under nutrition: can traditional practices offer a solution? Health Action. 2017;10(1):1327255
  7. Patwardhan B. Indian science and predatory journals. J AyurvedaIntegr Med. 2017;8(1):1.
  8. Patwardhan B, Tillu G. J-AIM: Progress, policy and future plans. J Ayurveda Integr Med. 2017;8(4):213-214.
  9. Sanap A, Chandravanshi B, Shah T, Tillu G, Dhanushkodi A, Bhonde R, Joshi K. Herbal preconditioning induces proliferation and delays senescence in Wharton's Jelly Mesenchymal Stem Cells. Biomed Pharmacother. 2017;93:772-778.
  10. Patwardhan K, Tillu G, Jadhav PM. Good practices of publishing AYUSH research: A practical checklist for authors. J Ayurveda Integr Med. 2017;8(2):132-136.
  11. Sundrani, D., Narang, A., Mehendale, S., et al. Investigating the expression of MMPs and TIMPs in preterm placenta and role of CpG methylation in regulating MMP-9 expression. IUBMB Life. 2017;69(12):985-993.
  12. Khot, VV., Yadav, DK., Shrestha, S. Hypermethylated CpG sites in the MTR gene promoter in preterm placenta. Epigenomics. 2017;9(7):985-996.
  13. Rani, A., Chavan-Gautam, P., Joshi, S. Omega-3 fatty acids and risk of preeclampsia. Lipid Technology. 2017;29(5-6):47-51.
  14. Singh, DP., Borse, SP., Rana, R., Nivsarkar, M. Curcumin, a component of turmeric, efficiently prevents diclofenac sodium-induced gastroenteropathic damage in rats: A step towards translational medicine. Food Chem Toxicol. 2017;108:43-52
  15. Singh, DP., Borse, SP., Nivsarkar, M. Overcoming the exacerbating effects of ranitidine on NSAID-induced small intestinal toxicity with quercetin: Providing a complete GI solution. Chem Biol Interact. 2017; 272:53-64.
  16. Singh, DP., Borse, SP., Nivsarkar, M. Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats. Exp Toxicol Pathol. 2017; 69(1):17-26.

2016

  1. Patwardhan B. Integrity of Ayurveda. J AyurvedaIntegr Med. 2016;7(4):189.
  2. Chaturvedi S, Patwardhan B. Building bridges for integrative medicine. Lancet Psychiatry. 2016;3(8):705-706.
  3. Patwardhan B. Ayurvedic drugs in case: claims, evidence, regulations and ethics. J AyurvedaIntegr Med. 2016;7(3):135.
  4. Patwardhan B. Strengthening the Ayurveda ecosystem. J AyurvedaIntegr Med. 2016;7(2):73.
  5. Patwardhan B. Strategic cooperation with WHO. J AyurvedaIntegr Med. 2016;7(1):1.
  6. Patwardhan B. Need to recognize efforts from developing countries. J Bioeth Inq. 2016;13(1):19-19.
  7. Roy A., Patwardhan B, Chaguturu R. Reigniting pharmaceutical innovation through holistic drug targeting. Drug Discovery World. 2016:45-55.
  8. Patwardhan B. A Primer on Yoga: Theory and Practice. Natl Med J India. 2016;29(1):32.
  9. Rani, A., Wadhwani, N., Chavan‐Gautam, P. and Joshi, S. Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids. WIREs Dev Biol. 2016;5:582-597.
  10. Singh, DP., Borse, SP., Nivsarkar, M. A novel model for NSAID induced gastroenteropathy in rats. J Pharmacol Toxicol Methods. 2016;78:66-75.
  11. Singh, DP., Borse, SP., Nivsarkar, M. Clinical importance of nonsteroidal anti-inflammatory drug enteropathy: the relevance of tumor necrosis factor as a promising target. Translational Research. 2016;175:76-91.

2015

  1. Ghodke-Puranik Y, Puranik AS, Shintre P., et al. Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis. Pharmacogenomics. 2015;16(18):2019-2034.
  2. Rotti H., Mallya S., Kabekkodu SP., et al. DNA methylation analysis of phenotype specific stratified Indian population. Transl. Med. 2015;13(1):1-12.
  3. Patwardhan B. The Living Tree: Traditional Medicine and Public Health in China and India. Curr. Sci. 2015;109 (9):1734-1736.
  4. Nizamuddin S., Govindaraj P., Saxena S., et al. A novel gene THSD7A is associated with obesity. Int J Obes. 2015;39(11):1662-1665.
  5. Govindaraj P., Nizamuddin S., Sharath A., et al. Genome-wide analysis correlates Ayurveda Prakriti. Sci Rep. 2015;5:15786.
  6. Patwardhan B. Ready for the next leap. J AyurvedaIntegr Med. 2015;6(4):223.
  7. Patwardhan B. Public perception of AYUSH. J AyurvedaIntegr Med. 2015;6(3):147.
  8. Patwardhan B. Good publications need good research. J AyurvedaIntegr Med. 2015;6(2),73.
  9. Patwardhan B. Traditional medicine-inspired evidence-based approaches to drug discovery. Evidence-Based Validation of Herbal Medicine. 2015;259-272.
  10. Patwardhan B, Chandran U. Network ethnopharmacology approaches for formulation discovery. Indian J Tradit Know. 2015;14(4).
  11. Patwardhan B. National health policy: Need to innovate. J AyurvedaIntegr Med. 2015;6(1):1.
  12. Raut A., Tillu G., Vaidya A.. Reverse Pharmacology Effectuated by the Studies of Ayurvedic Products for Arthritis. Curr Sci. 2015;111(2):337-342.
  13. Patwardhan B., Deshpande S., Tillu G., Mutalik G. In Search of Roots: Tracing the History and Philosophy of Indian Medicine. Ind J His Sci. 50(4);2015:629-641.
  14. Jadhav S., Jain R., Dhumal P., Tillu G., Hegde V. Prevalence and prevention of musculoskeletal pain in conservative dentistry and endodontics: An online survey. Universal Research Journal of Dentistry. 2015;5(3):189.
  15. Gadhave S., Sardeshpande N., Tillu G., Patwardhan B. Human resource for health and medicine: Need for clear approach. Econ Polit Wkly. 2015;36:77-78
  16. Chandran U., Mehendale N., Tillu G., Patwardhan B. Network Pharmacology of Ayurveda Formulation Triphala with Special Reference to Anti-Cancer Property. Comb Chem HighThroughput Screen. 2015:18.
  17. Chandran U., Mehendale N., Tillu G., Patwardhan B. Network Pharmacology: An Emerging Technique for Natural Product Drug Discovery and Scientific Research on Ayurveda. Proc Indian Natn Sci Acad. 2015;81(3):1-8.
  18. Tillu G., Sarmukaddam S., Chopra A., Tharyan P. Ayurveda interventions for Rherumatoid Arthritis. (Protocol). Cochrane Database Syst Rev. 2015;(3):CD011569.
  19. Sable P., Randhir K., Kale A., Chavan-Gautam P., Joshi S. Maternal micronutrients and brain global methylation patterns in the offspring.Nutr Neurosci. 2015;18(1)30-36.
  20. Khot V., Chavan-Gautam P., Joshi S. Proposing interactions between maternal phospholipids and the one carbon cycle: A novel mechanism influencing the risk for cardiovascular diseases in the offspring in later life. Life Sciences. 2015;129:16-21.
  21. Rani A., Chavan-Gautam P., Mehendale S., Wagh G., Joshi S. Differential regional fatty acid distribution in normotensive and preeclampsia placenta. BBA Clinical. 2015;4:21-26.

Books/Book Chapters

  1. Borse SP,Kulkarni AS, Koshi H, Vasu KK, Nivsarkar M. Toxicology aspect of turmeric. Royal Society of Chemistry; 2020.
  2. Chavan-Gautam P, Shah T, Joshi K. Transcriptomics and Epigenomics. In: Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting. Academic Press, Elsevier; 2017. 235-272
  3. Tillu G, Patwardhan B. Holistic Lifestyle. In: Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting. Academic Press, Elsevier; 2017.
  4. Patil D, Patwardhan B, Kumbhare K. Why and How Drugs Fail. In: Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting. Academic Press, Elsevier; p. 23-64.
  5. Bhushan Patwardhan, Gururaj Mutalik, Girish Tillu. Integrative Approaches for Health: Biomedical Research, Ayurveda, and Yoga. 1st Academic Press, Elsevier; 2015

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