RNG RESEARCH GROUP (Mo.9423656179)

• Natural Product & targeted drug development against Cancer and Diabetes with mechanism of action.
• Cancer Biology (Angiogenesis, tumour heterogeneity, EMT, Apoptosis, Cancer Epigenetics).
• Applications of Computational tools for SAR &drug development

Research Group:
PhD Students: Mr. Sharad Tat, Mr. Shridhar Chougule, Pallavi Shewale, Jasoda Parmar
Post-Doctoral Fellows: 1. Dr. Navnath Kumbhar (SPPU-PDF Fellow); 2. Dr. Upasana Kapoor (DS Kothari Fellow).

Group Description: We are in the midst of ‘target rich lead poor scenario’ as the evolving drug targets are not being compensated by the novel and effective leads. In the current state of the art, over 60% anticancer drugs that are prescribed the physician are basically derived from the natural products mostly from plants, marine organisms, and microorganisms. The anticancer activity of most natural products often act via regulating cell proliferation pathways, immune function, inducing apoptosis or autophagy, or inhibiting cell proliferation. Our lab is working on identification of evidence based novel leads from natural sources that can be validated against several anti-cancer and anti-diabetic drug targets with possible molecular mechanisms. Parallel to this our lab has also focus of addressing the basic molecular aspects of cancer biology and diabetes in relation drug resistance, epigenetics, tumour heterogeneity, EMT and apoptosis.

Publications: (Last five years)

1. Rohan J Meshram, et al..& Rajesh N Gacche (2019) Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2019.1597770.

2. Kapil K Patil, et al & Rajesh N Gacche (2019). 3Biotech, 9:47 https://doi.org/10.1007/s13205-019-1581-3.

3. Sonali S. Kamble and Rajesh N. Gacche. (2019).. European Journal of Integrative Medicine 25, 13-19.

4. Utage B.G. et al, Gacche R.N. (2018). J. Oncotarget 9 (54), 30304-30323.

5. Rajesh N. Gacche, Yehuda G. Assaraf, (2018). Drug Resistance Updates 36, 47-76.

6. Kolte BS, et al.. Gacche RN (2018). J Mol Graph Model. 80, 95-103.

7. Meshram, RJ et al.. Rajesh N Gacche. (2018). J. Parasitology International 69, 59-70.

8. Kapil K. Patil, Rajesh N. Gacche (2017). International Journal of Biological Macromolecules 98, 730-738.

9. Patil KK, Meshram RJ, Gacche RN. (2016). J Enzyme Inhib Med Chem. 5:1-9.

10. Patil, KK. et al.. Rajesh N Gacche (2016). Archives of Biochem and Biophys 593, 1-11

11. Shaikh RU, et al. Gacche RN (2015). Phytother Res. 30, 412-417.

12. Sonali Kamble, et al.. (2016). AAPS Pharm Sci Tech.DOI: 10.1208/s12249-015-0435-5

13. Gacche RN (2015) Nature-Oncogenesis 4, e153; doi:10.1038/oncsis.2015.14.

14. Gacche RN, et al (2015). Archives of Biochemistry and Biophysics 577-578, 35-48.

15. Meshram RJ and Gacche RN (2015). J. Molecular Recognition. DOI: 10.1002/jmr.2466