Fugal Pathogenesis and Metabolic engineering (Mo.9975922727)

• Drug Resistance mechanisms.
• Natural Molecules.
• Metabolic Engineering.

Group Description:(max. 100 words)
The past few decade have witness of remarkable increment in immune compromised patients includes, neonates, pregnant women, post-operative, HIV positive cancer and diabetic patients. Eventually there is significant raise in opportunistic infections in which Candida infections are predominant. Although Candida albicans remains the most common pathogenic fungi encountered, Non albicans Candida infections are increasing leading to cause high mortality and morbidity rate. Our lab is working in elucidating the resistance mechanism of Non- albicans Candida to the antifungals and role of natural molecules as new antifungals. Our lab is also deals with research in metabolic engineering of human health related biomolecules produced in GRAS yeast.

Publications: (Last five years)

• Dofe, V.S., Sarkate, A.P., Lokwani, D.K., Kathwate, S.H., Gill, C.H. (2017). Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based 1, 2, 3-triazoles. Research on Chemical Intermediates, 43 (1), 15-28. WoS Citations: 6, ISSN(print/online): 0922-6168/1568-5675, URL/DOI: http://dx.doi.org/10.1007/s11164-016-2602-z

• Dofe, V. S., Sarkate, A. P., Lokwani, D. K., Shinde, D. B., Kathwate, S. H., & Gill, C. H. (2017). Novel O‐Alkylated Chromones as Antimicrobial Agents: Ultrasound Mediated Synthesis, Molecular Docking and ADME Prediction. Journal of Heterocyclic Chemistry, 54(5), 2678-2685.

• Dofe, V. S., Sarkate, A. P., Kathwate, S. H., & Gill, C. H. (2017). Synthesis, antimicrobial activity and anti-biofilm activity of novel tetrazole derivatives. Heterocyclic Communications, 23(4), 325-330.

• Kathwate, G.H., Karuppayil, S.M. (2017). Tramadol, an Opioid Receptor Agonist: An Inhibitor of Growth, Morphogenesis, and Biofilm Formation in the Human Pathogen, Candida albicans. ASSAY and Drug Development Technologies, 14 (10), 567-572. WoS Citations: 2, ISSN(print/online): 1540-658X/1557-8127, URL/DOI: http://dx.doi.org/10.1089/adt.2016.760

• Kathwate, G. H., Shinde, R. B., & Karuppayil, S. M. (2015). Antiepileptic drugs inhibit growth, dimorphism, and biofilm mode of growth in human pathogen Candida albicans. Assay and drug development technologies, 13(6), 307-312.

• Kathwate, G.H., Karuppayil, S.M. (2013). Antifungal properties of the anti-hypertensive drug: Aliskiren. Archives of Oral Biology, 58 (9), 1109-1115. Google Scholar Citations: 5, WoS Citations: 8, ISSN(print/online): 0003-9969/1879-1506, URL/DOI: http://dx.doi.org/10.1016/j.archoralbio.2013.02.006