Dr. Amul Sakharkar |
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Neuro Epigenetics and Neurobiology Lab (Mo.9130005947) |
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Key research interests: |
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Research Group: |
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Group Description: Chromatin remodeling is sculpted by many intricate processes, collectively known as epigenetic mechanisms, such as post-translational modifications (PTMs) and DNA methylation/demethylation. Neurons, being the post-mitotic cells, possibility of accumulation of such epigenetic alterations during its rather long life span are intense. Our laboratory focuses on three different aspects with common interest in understanding the neuroepigenetic basis of neurobiology. In one of the project, our lab is investigating epigenetic regulation of oxidative phosphorylation (OXPHOS) and energy metabolism in the brain. Secondly, our lab is interested in elucidating the neural underpinnings of reward memories. Gut microbiome exert profound impact on neural function; does gut microbiome contribute to chromatin architecture in specific areas of the brain, is the question our lab is trying to address. |
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Publications: |