Chromatin and Gene Regulation Lab (Mo.9850858073)

• Chromatin Dynamics.

• Epigenetic regulation of gene expression.

• Regulation and function of non-coding RNAs.

Group Description:Our lab works on understanding the chromatin dynamics, which is crucial for regulation of gene expression (coding and non-coding RNAs namely miRNAs and lncRNAs) required for normal functioning of cell. Gene expression regulation is involved in many biological processes including development and differentiation. Understanding this basic regulation and expression will give insight in designing biomarkers and therapeutic drugs for various diseases. In our lab, we use cancer cells and also human mesenchymal stem cells to understand regulation of specific genes and non-coding RNAs during development and differentiation.

Publications: (Last five years)

1. Nitin Narwade, Sonal Patel, Aftab Alam, Samit Chattopadhyay*, Smriti Mittal* and Abhijeet Kulkarni1*(2019). Mapping of scaffold/matrix attachment regions in human genome: A data mining exercise. Nucleic Acids Research. (Accepted). IF: 11.561.

*Corresponding Author

2. Swati Khole, Smriti Mittal, Nidhi Jagadish, Debjani Ghosh, Sharmilli Chettiar, Vivek Singh, Aarti Desai, Vilas Sinkar, Vijay Gadgil, Saroj Ghaskadbi (2019). Andrographolide enhances redox status of liver cells through differential microRNA expression. Free Radic. Biol. Med. 130, 397-407. IF: 6.020.

3. Sajjad A Malik, Swati Khole, Smriti Mittal, T. Urmode, R. Kusurkar, Saroj S. Ghaskadbi (2019). Differential response of antioxidant defense in HepG2 cells on exposure of Livotrit®, in a concentration dependent manner. J. Trad. Compl. Med. 9, 38-44.

4. Hoda Aayadi, Smriti Mittal, Anjali Deshpande, Makarand Gore, Saroj S Ghaskadbi (2017). Cytoprotective effect exerted by geraniin in HepG2 cells is through microRNA mediated regulation of BACH-1 and HO-1. BMB Reports, pii: 3815. IF: 3.089.

5. Hoda Aayadi, Smriti Mittal, Anjali Deshpande, Makarand Gore, Saroj S Ghaskadbi (2017). Protective effect of geraniin against carbon tetrachloride induced acute hepatotoxicity in Swiss albino mice. Biochem Biophys Res Commun. 487, 62-67. IF: 2.371.

6. Smriti Mittal, Swati Khole, Nidhi Jagadish, Debjani Ghosh,Vijay Gadgil, Vilas Sinkar, Saroj S. Ghaskadbi (2016). Andrographolide protects liver cells from H2O2 induced cell death via upregulating Nrf-2/HO-1 through Adenosine A2a receptor mediated signaling.

Biochim Biophys Acta-General Subjects. 1860, 2377-90. IF: 5.083. 7. Abhijeet P. Kulkarni* and Smriti Mittal (2016). Sequence data mining in search of hookworm (Necator americanus) microRNAs. Gene. 590, 317-323. IF: 2.319.

8. Jinumary Mathai, Smriti Mittal, Aftab Alam, Payal Ranade, Devraj Mogare, Sonal Patel, Smita Saxena, Suvankar Ghorai, Abhijeet P. Kulkarni and Samit Chattopadhyay (2016). SMAR1 binds to [T(CG)]10 consensus motif and inhibits tumor progression by regulating miR-371-373 cluster. Scientific Reports (NPG). 6, 33779. IF: 5.228

9. Smriti Mittal, Abhijeet P. Kulkarni, Jinumary Mathai, Samit Chattopadhyay and Jayanta K. Pal (2014). Dose-dependent differential response of mammalian cells to cytoplasmic stress is mediated through the heme-regulated eIF-2a kinase. Int. J. Biochem. Cell Biol. 54, 186-197. IF: 3.905